Monoclonal antibody anti-PBP2a protects mice against MRSA (methicillin-resistant Staphylococcus aureus) infections
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چکیده
منابع مشابه
Methicillin Resistant Staphylococcus aureus (MRSA)
Staphylococcus aureus is responsible for a broad range of clinical infections, most notable of which are cases of bacteremia and endocarditis. Staphylococcus aureus is an important cause of serious infections in both hospitals and the community. Methicillin-resistant Staphylococcus aureus (MRSA) were first reported in 1961 and the first hospital outbreak of MRSA was reported in 1963. When MRSA ...
متن کاملMethicillin Resistant Staphylococcus aureus (MRSA)
Staphylococcus aureus is an opportunistic pathogen often carried asymptomatically on the human body. Methicillin-resistant S. aureus (MRSA) includes those strains that have acquired a gene giving them resistance to methicillin and essentially all other beta-lactam antibiotics. MRSA was first reported in 1961, soon after methicillin was introduced into human medicine to treat penicillinresistant...
متن کاملMethicillin-Resistant Staphylococcus aureus (MRSA)
Background Active Bacterial Core surveillance (ABCs) is a core component of the Emerging Infections Program (EIP) Network sponsored by the Centers for Disease Control and Prevention (CDC). The purpose of ABCs is to determine the incidence and epidemiologic characteristics of invasive disease due to Haemophilus influenzae, Neisseria meningitidis, group A Streptococcus (GAS), group B Streptococcu...
متن کاملMethicillin-resistant Staphylococcus aureus (MRSA)
MRSA was isolated from pus, urine, breast discharge, blood culture, cerebrospinal fluid, and ascetic fluid [2]. The extensive use of antibiotics over the last 50 years has led to the emergence of bacterial resistance and to the dissemination of resistance genes among pathogenic organisms [3]. In addition, since few cells in a population might actually express resistance, these heterogeneous str...
متن کاملDetection of methicillin-resistant Staphylococcus aureus using a specific anti-PBP2a chicken IgY antibody.
Immunodetection of methicillin-resistant Staphylococcus aureus (MRSA) by conventional methods employing mammalian immunoglobulins has unknown detection limits, and often yields false-positive results because of the presence of S. aureus protein A, which binds the Fc region of mammalian IgG. In this study, a new PBP2a-specific chicken IgY antibody was developed in inbred and conventional chicken...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0225752